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Treatment with NaIO 4 affords the useful synthon 2,3-O-isopropylidene-D-glyceraldehyde (glyceraldehyde acetonide): J. Org. Chem., 56, 4056 (1991); Org. Synth. Coll., 9, 450 (1998). This in turn can be homologated diastereoselectively using 2-(Trimethylsilyl)thiazole, B21903: Org. Synth. Coll., 9, 52 (1998). For use of Pb(OAc) 4 in the formation of glyceraldehyde acetonide as a chiral precursor of cyclopropyl carbocyclic nucleosides as HIV reverse transcriptase inhibitors, see: J. Org. Chem., 60, 5236 (1995)./n
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