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57260-71-6 - 1-Boc-piperazine, 99% - 1-(tert-Butoxycarbonyl)piperazine - tert-Butyl 1-piperazinecarboxylate - L13363 - Alfa Aesar

L13363 1-Boc-piperazine, 99%

CAS-Nummer
57260-71-6
Synonyme
1-(tert-Butoxycarbonyl)piperazine
tert-Butyl 1-piperazinecarboxylate

Größe Preis ($) Menge Verfügbarkeit
1g 23,22
5g 82,53
25g 321,30
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1-Boc-piperazine, 99%

MDL
MFCD00075265

Chemische Eigenschaften

Formel
C9H18N2O2
Molmasse
186.26
Schmelzpunkt
44-48°
Sensitivität
Air Sensitive
Löslichkeit
Soluble in ethyl acetate, methanol and water.

Anwendungen

1-Boc-piperazine is useful for the preparation of (m-phenoxy)phenyl substituted piperazine derivatives. It is also used in the synthesis of indazole DNA gyrase inhibitors. Further, it plays an important role in the preparation of alfa,beta-poly(2-oxazoline) lipopolymers through living cationic ring opening polymerization. It is also in involved in Buchwald-Hartwig coupling reactions with aryl halides.

Bemerkungen

Hygroscopic. Store in a cool place. Moisture sensitive. Incompatible with strong oxidizing agents.

Literaturverweise

Pd-catalyzed C-N coupling with a variety of bromoarenes, in the presence of NaO-t-Bu and Tri(o-tolyl)­phosphine, A12093, provides a route to arylpiperazines of potential pharmacological interest: Tetrahedron Lett., 39, 2219 (1998).

Ba-Salem, A. O.; Shaikh, M. N.; Ullah, N.; Faiz, M. Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines. Inorg. Chem. Commun. 2015, 56, 5-7.

Nemeckova-Herova, D.; Pazdera, P. A Simplified Protocol for Routine Chemoselective Syntheses of Piperazines Substituted in the 1-Position by an Electron Withdrawing Group. Curr. Org. Synth. 2015, 12 (2), 173-179.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
879985
Harmonized Tariff Code
2933.59
TSCA
No

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