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Trimethyl orthoacetate is used as a diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange. It is mainly used as the chemical intermediates of the medicine. Some of the other applications includes it is mainly used as chemical intermediate of pharmaceutical and agricultural chemicals, used for compound medical intermediates of vitamin B1, vitamin A1 and sulfanilamide organism, used for dye and spices industry, Medicine, agricultural chemicals, paint additives.
HPM Fromageot.; BE Griffin.; CB Reese.; JE Sulston. The synthesis of oligoribonucleotidesIII: Monoacrylation of ribonucleosides and derivativesvia orthoester exchange. Tetrahedron. 1967, 23,(5), 2315-2331.
T Yoshino.; S Imori.; H Togo. Efficient esterification of carboxylic acids and phosphonic acids with trialkyl orthoacetate in ionic liquid. Tetrahedron. 2006, 62,(6), 1309-1317.
Diols can be protected as their 1-methoxyethylidene cyclic acetals (2-methoxy-2-methyl-1,3-dioxolanes) by acid-catalyzed exchange; see, e.g.: J. Am. Chem. Soc., 95, 278 (1973). See also Triethyl orthoacetate, L06004.
Gefahrenhinweise (EU): H225-H315-H319-H335
Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.