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2,4,6-Trichlorobenzoyl chloride is used in the preparation of γ-lactone and δ-lactone, aliphatic aromatic anhydrides, required for the synthesis of amphiphilic hyaluronan, mixed anhydride, required for the synthesis of angelate esters, synthesis of both spongistatin 1 and spongistatin 2 and large-ring lactones in high yields.
Gloria Huerta-Angeles.; Martin Bobek.; Eva P?íkopová.; Daniela Šmejkalová.; Vladimír Velebný. Novel synthetic method for the preparation of amphiphilic hyaluronan by means of aliphatic aromatic anhydrides. .Carbohydrate Polymers 2014, 111 883-891.
Machiko Ono.; Keisuke Kato.; Hiroyuki Akita. Synthesis of γ- and δ-lactone natural products by employing a trans-cis isomerization/lactonization strategy. Chemical & Pharmaceutical Bulletin. 2013, 61 (4), 464-470.
Reagent, introduced by Yamaguchi, which forms mixed anhydrides with acids, useful in the synthesis of esters: Bull. Chem. Soc. Jpn., 52, 1989 (1979), or lactones including macrolides: Chem. Lett., 1021 (1979). Superior to mesitylenesulfonyl chloride for macrolactonization, which has been achieved in the presence of DMAP without the need for high dilution: J. Org. Chem., 55, 7 (1990); Tetrahedron Lett., 31, 6367 (1990).
Gefahrenhinweise (EU): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
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