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trans,trans-Farnesol is an intermediate used in the biological synthesis of cholesterol from mevalonic acid. It is used in the perfume industry. Further, it is used in the preparation of terpenes such as squalenes, cembranoids and forskolin. It is also used in the synthesis of Cecropia juvenile hormone.
Terpene building block.
A convenient 2-step alternative to the Gabriel or azide displacement methods for the synthesis of allylic amines has been reported using a Mitsunobu reagent (from Diisopropyl azodicarboxylate, L10386) in combination with phthalimide, followed by mild deprotection with methylamine. This technique avoids the allylic rearrangements and other side reactions associated with the older routes: Synthesis, 756 (1995):
Espinosa, R. R.; Inchingolo, R.; Alencar, S. M.; Rodriguez-Estrada, M. T.; Castro, I. A. Antioxidant activity of phenolic compounds added to a functional emulsion containing µ-3 fatty acids and plant sterol esters. Food Chem. 2015, 182, 95-104.
Nikoli?, B.; Risti?, M.; Bojovi?, S.; Krivošej, Z.; Matevski, V.; Marin, P. D. Population Variability of Essential Oils of Pinus heldreichii from the Scardo-Pindic Mountains Ošljak and Galičica. Chem. Biodivers. 2015, 12 (2), 295-308.
Gefahrenhinweise (EU): H319
Causes serious eye irritation.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.