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961-07-9 - 2'-Deoxyguanosine hydrate, 99% - 9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate - Guanine-2'-deoxyriboside hydrate - L14519 - Alfa Aesar

L14519 2'-Deoxyguanosine hydrate, 99%

CAS-Nummer
961-07-9
Synonyme
9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate
Guanine-2'-deoxyriboside hydrate

Größe Preis ($) Menge Verfügbarkeit
100mg 42,70
500mg 150,00
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2'-Deoxyguanosine hydrate, 99%

MDL
MFCD00150760
EINECS
213-505-8

Chemische Eigenschaften

Formel
C10H13N5O4•xH2O
Molmasse
267.25(anhy)
Löslichkeit
Slightly soluble in water.

Anwendungen

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Bemerkungen

Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Kasper Broedbaek; Allan Weimann; Elisabeth S. Stovgaard; Henrik E. Poulsen. Urinary 8-oxo-7,8-dihydro-2?-deoxyguanosine as a biomarker in type 2 diabetes. Free Radical Biology and Medicine2011, 51(8), 1473-1479.

Aaron M Fleming; Arunkumar Kannan; James G Muller; Yi Liao; Cynthia J Burrows. Copper/H2O2-mediated oxidation of 2'-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts. Journal of Organic Chemistry,2011, 76 (19), 7953-7963.

GHS Gefahren- und Sicherheitshinweise

Sicherheitshinweise: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
39814
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
MF8760000

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