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112022-81-8 - (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene - (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole - L14583 - Alfa Aesar

L14583 (S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

CAS-Nummer
112022-81-8
Synonyme
(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Größe Preis ($) Menge Verfügbarkeit
1ml 32,94
5ml 69,75
25ml 230,72
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

(S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene

MDL
MFCD00078439

Chemische Eigenschaften

Formel
C18H20BNO
Molmasse
277.17
Flammpunkt
4°(39°F)
Dichte
0.925
Sensitivität
Air & Moisture Sensitive
Löslichkeit
Hydrolyzes in water.

Anwendungen

(S)-2-Methyl-CBS-oxazaborolidine is used as an oxazaborolidine catalyst. It is also employed in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols and propargyl alcohols. It is an anhydrous catalyst for 'CBS' reduction reaction.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Literaturverweise

Panayiotis A Procopiou.; Gillian E Morton.; Martin Todd.; Graham Webb. Enantioselective synthesis of (S)-salmeterol via asymmetric reduction of azidoketone by Pichia angusta. Tetrahedron: Asymmetry. 2001, 12 (14), 2005-2008.

Toshiyasu Takemoto.; Katsuyoshi Nakajima.; Yukiko Iio, Masakazu Tamura.; Takahide Nishi. Asymmetric synthesis of enantiomerically pure spiro[((2S)-hydroxy)indane-1,4?-piperidine]. Tetrahedron: Asymmetry. 1999, 10 (9), 1787-1793.

Anhydrous catalyst for 'CBS' reduction reaction. For examples of use in asymmetric reduction of ketones, see: Org. Synth. Coll., 9, 362, 676 (1998). For further information, see (S)-2-Methyl-CBS-oxazaborolidine monohydrate, L09219.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H304-H361-H373-H315-H336

Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes skin irritation. May cause drowsiness or dizziness.

Sicherheitshinweise: P210-P260-P201-P261-P280-P281-P301+P310-P303+P361+P353-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2934.99
TSCA
No

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