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4487-59-6 - 2-Bromo-5-nitropyridine, 98+% - L15661 - Alfa Aesar

L15661 2-Bromo-5-nitropyridine, 98+%

CAS-Nummer
4487-59-6
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 24,60
5g 76,10
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2-Bromo-5-nitropyridine, 98+%

MDL
MFCD00006222
EINECS
224-777-2

Chemische Eigenschaften

Formel
C5H3BrN2O2
Molmasse
203.00
Schmelzpunkt
136-140°
Siedepunkt
145-147°/10mm
Löslichkeit
Insoluble in water.

Anwendungen

2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literaturverweise

Spencer J, et al. Synthesis of a (piperazin-1-ylmethyl) biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings.. Tetrahedron Lett. 201152 (31), 3963-68.

Hashim Motiwala et. al. Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorganic & Medicinal Chemistry Letters, . 2011, 21 (19), 5812-5817.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H312-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Beilstein
120901
Harmonized Tariff Code
2933.39
TSCA
No

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Metalle und Stoffe

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