I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Lithium amide is used in the preparation of active pharmaceutical ingredients and antioxidants. It acts as a catalyst for polymers, as nucleophiles and as strong bases. It serves as a reagent in the synthesis of antiinflamatory and preoresolving protectin D1, chemotype dipeptidyl peptidase IV inhibitors and sterically congested triarylamines. It finds application in dyes displaying large stokes shifts. In addition to this, it is used as a reagent for cross-coupling of aryl chlorides and amine.
Sasaki, M.; Kondo, Y.; Moto-ishi, T. I.; Kawahata, M.; Yamaguchi, K.; Takeda, K. Enantioselective Synthesis of Allenylenol Silyl Ethers via Chiral Lithium Amide Mediated Reduction of Ynenoyl Silanes and Their Diels-Alder Reactions. Org. Lett. 2015, 17 (5), 1280-1283.
Lesage, D.; Barozzino-Consiglio, G.; Duwald, R.; Fressigné, C.; Harrison-Marchand, A.; Faull, K. F.; Maddaluno, J.; Gimbert, Y. A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl. J. Org. Chem. 2015, 80 (12), 6441-6446.
Gefahrenhinweise (EU): H261-H314-H318
In contact with water releases flammable gas. Causes severe skin burns and eye damage. Causes serious eye damage.
Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor In case of fire: Use for extinction: Limestone powder. Store in a dry place.