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1795-48-8 - Isopropyl isocyanate, 98+% - L16105 - Alfa Aesar

L16105 Isopropyl isocyanate, 98+%

CAS-Nummer
1795-48-8
Synonyme

Isopropyl isocyanate, 98+%

MDL
MFCD00002037
EINECS
217-276-5

Chemische Eigenschaften

Formel
(CH3)2CHNCO
Molmasse
85.11
Siedepunkt
74-75°
Flammpunkt
-3°(26°F)
Dichte
0.868
Brechungsindex
1.3840
Sensitivität
Moisture Sensitive
Löslichkeit
Immiscible with water.

Anwendungen

Isopropyl isocyanate is used as a reagent in the preparation of androgen receptor antagonist for prostate cancer treatment. It is also used in the synthesis of selective dual inhibitor of mammalian target of rapamycin (mTORC1 and mTORC2). Further, it serves as a reagent in the synthesis of O-aryl N-isopropylcarbamates. In addition to this, it is used as a derivatization reagent during the stereoisomeric analysis of secondary alcohols.

Bemerkungen

Moisture sensitive. Incompatible with water, alcohols, strong bases, amines, acids and strong oxidizing agents.

Literaturverweise

Otto, A.; Grube, T.; Schiebahn, S.; Stolten, D. Closing the loop: captured CO2 as a feedstock in the chemical industry. Energy Environ. Sci. 2015, 8 (11), 3283-3297.

Zou, L.; Wang, X. Y.; Zhang, X. X.; Dai, Y. Z.; Wu, Y. D.; Wang, J. Y.; Pei, J. Toward electron-deficient pyrene derivatives: construction of pyrene tetracarboxylic diimide containing five-membered imide rings. Chem. Commun. 2015, 51 (63), 12585-12588.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H330-H315-H319-H335-H334

Highly flammable liquid and vapour. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Sicherheitshinweise: P210-P260-P284-P285-P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. In case of inadequate ventilation wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
969356
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2929.10
TSCA
Yes

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