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50-91-9 - 5-Fluoro-2'-deoxyuridine, 98+% - 2'-Deoxy-5-fluorouridine - Floxuridine - L16497 - Alfa Aesar

L16497 5-Fluoro-2'-deoxyuridine, 98+%

CAS-Nummer
50-91-9
Synonyme
2'-Deoxy-5-fluorouridine
Floxuridine

Größe Preis ($) Menge Verfügbarkeit
100mg 80,00
500mg 264,00
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5-Fluoro-2'-deoxyuridine, 98+%

MDL
MFCD00006530
EINECS
200-072-5

Chemische Eigenschaften

Formel
C9H11FN2O5
Molmasse
246.20
Schmelzpunkt
148-151°
Löslichkeit
Soluble in water, alcohol, isopropyl alcohol, methanol, aqueous buffers, acetone, dimethyl sulfoxide, and ethanol. Insoluble in ether, benzene and chloroform.

Anwendungen

5-Fluoro-2'-deoxyuridine acts as an antiviral and antineoplastic agent. It is also employed for renal function diagnosis. Further, it is used as an experimental anticancer agent, which shows activity against a variety of malignant neoplasms. It is also used as an inhibitor of thymidylate synthetase and DNA synthesis. In addition to this, it plays an important role in the treatment of colorectal cancer.

Bemerkungen

Store in a cool place.Incompatible with strong oxidizing agents and strong bases.

Literaturverweise

Rooney, J. P.; Luz, A. L.; Gonzalez-Hunt, C. P.; Bodhicharla, R.; Ryde, I. T.; Anbalagan, C.; Meyer, J. N. Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. Exp. Gerontol. 2014, 56, 69-76.

Kruspe, S.; Hahn, U. An Aptamer Intrinsically Comprising 5-Fluoro-2'-deoxyuridine for Targeted Chemotherapy. Mol. BioSyst. 2014, 53 (39), 10541-10544.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H360-H341-H302

May damage fertility or the unborn child. Suspected of causing genetic defects. Harmful if swallowed.

Sicherheitshinweise: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,4112
Beilstein
2645818
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
YU7535000

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