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65094-22-6 - Diethyl (bromodifluoromethyl)phosphonate, 97% - Bromodifluoromethyl diethyl phosphonate - Diethyl bromodifluoromethanephosphonate - L16715 - Alfa Aesar

L16715 Diethyl (bromodifluoromethyl)phosphonate, 97%

CAS-Nummer
65094-22-6
Synonyme
Bromodifluoromethyl diethyl phosphonate
Diethyl bromodifluoromethanephosphonate

Größe Preis ($) Menge Verfügbarkeit
1g 22,70
5g 65,90
25g 251,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Diethyl (bromodifluoromethyl)phosphonate, 97%

MDL
MFCD00069118

Chemische Eigenschaften

Formel
C5H10BrF2O3P
Molmasse
267.01
Siedepunkt
99-102°/16mm
Flammpunkt
>110°(230°F)
Dichte
1.503
Brechungsindex
1.4160
Löslichkeit
Not miscible or difficult to mix in water.

Anwendungen

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Literaturverweise

Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.

Katherine A Rawls.; Christoph Grundner.; Jonathan A Ellman. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic & Biomolecular Chemistry. 2010, 8 (18), 4066-4070.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319

Causes skin irritation. Causes serious eye irritation.

Sicherheitshinweise: P260-P201-P280g-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1944045
Harmonized Tariff Code
2931.39
TSCA
No

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