I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.
Pijus K Mandal.; Fengqin Gao.; Zhen Lu.; Zhiyong Ren.; Rajagopal Ramesh.; J Sanderson Birtwistle.; Kumaralal K Kaluarachchi.; Xiaomin Chen.; Robert C Bast.; Warren S Liao.; John S McMurray. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (10), 3549-3563.
Katherine A Rawls.; Christoph Grundner.; Jonathan A Ellman. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Organic & Biomolecular Chemistry. 2010, 8 (18), 4066-4070.
Gefahrenhinweise (EU): H315-H319
Causes skin irritation. Causes serious eye irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.