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It is a reactant for Click/aza-Michael or Click/oligomeric alkyl carbodiimide esterification reactions, preparation of aminopyrazole amide derivatives as Raf kinase inhibitors in melanoma cells and preparation of trifluoromethoxyphenyl(thiazolyl)pyrroles and other heterocycle-bearing polyfunctionalized pyrroles via chain heterocyclization.
B. Chandrakantha.; Prakash Shetty.; Vijesh Nambiyar.; Nishitha Isloor.; Arun M. Isloor. Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety.European Journal of Medicinal Chemistry. 2010, 45 (3),1206-1210 .
Peter S. Dragovich.; Thomas J. Prins.; Ru Zhou.; Theodore O. Johnson.; Edward L. Brown.; Fausto C. Maldonado.; Shella A. Fuhrman.; Leora S. Zalman.; Amy K. Patick.; David A. Matthews.; Xinjun Hou.; James W. Meador III.; Rose Ann Ferr.; Stephen T. Worland. Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure-Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics.Bioorg. Med. Chem. Lett. . 2002, 12 (5),733-738 .
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.