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19493-44-8 - 1-Chloroisoquinoline, 95% - L17831 - Alfa Aesar

L17831 1-Chloroisoquinoline, 95%

CAS-Nummer
19493-44-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 27,89
5g 93,26
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1-Chloroisoquinoline, 95%

MDL
MFCD00024134
EINECS
000-000-0

Chemische Eigenschaften

Formel
C9H6ClN
Molmasse
163.61
Schmelzpunkt
33-35°
Siedepunkt
105-108°/4mm
Flammpunkt
>110°(230°F)
Löslichkeit
Insoluble in water.

Anwendungen

The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.

Bemerkungen

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literaturverweise

Kelvin Billingsley and Stephen L Buchwald. Highly efficient monophosphine-based catalyst for the palladium-catalyzed suzuki-miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.J. Am. Chem. Soc.,2007,129(11), 3358-3366.

Chang, et al. Homocoupling of aryl iodides and bromides using a palladium/indium bimetallic system.Synth. Commun.,2005,35(13), 1851-1857.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
2996
Harmonized Tariff Code
2933.49
TSCA
No

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