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5856-77-9 - 2,2-Dimethylbutyryl chloride, 98% - L18125 - Alfa Aesar

L18125 2,2-Dimethylbutyryl chloride, 98%

CAS-Nummer
5856-77-9
Synonyme

Größe Preis ($) Menge Verfügbarkeit
10g 32,60
50g 91,20
250g 294,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

2,2-Dimethylbutyryl chloride, 98%

MDL
MFCD03093071
EINECS
227-478-5

Chemische Eigenschaften

Formel
C6H11ClO
Molmasse
134.61
Siedepunkt
133°
Flammpunkt
29°(84°F)
Dichte
0.980
Brechungsindex
1.4240
Sensitivität
Moisture Sensitive
Löslichkeit
Reacts with water. Soluble in chloroform and ethyl acetate.

Anwendungen

,2-Dimethylbutanoyl chloride is a reagent that is used in the synthesis of 4α,5-Dihydro Simvastatin, the drug, is sold under the trade name Zocor. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic.

Bemerkungen

Moisture sensitive. Store away from water/moisture, strong bases and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep ignition sources away. Protect from electrostatic charges.

Literaturverweise

W. F. Hoffman, et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin.J. Med. Chem.,1986,29(5), 849-852.

G. E. Stokker, et al. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidene)-3,5-dihydroxyhexanoic acids and their lactone derivatives.J. Med. Chem.,1986,29(5), 852-855.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H314-H318

Flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1743935
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
No

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