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442-51-3 - Harmine, 98+% - 6-Methoxyharmane - 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole - L19068 - Alfa Aesar

L19068 Harmine, 98+%

CAS-Nummer
442-51-3
Synonyme
6-Methoxyharmane
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

Größe Preis ($) Menge Verfügbarkeit
250mg 41,60
1g 100,00
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Harmine, 98+%

MDL
MFCD00004958
EINECS
207-131-4

Chemische Eigenschaften

Formel
C13H12N2O
Molmasse
212.25
Schmelzpunkt
262-266°
Löslichkeit
Soluble in DMSO (100 mM), DMF (~1.5 mg/ml), ethanol (~1.5 mg/ml), and PBS (pH 7.2, ~0.25 mg/ml). Insoluble in water.

Anwendungen

Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

Bemerkungen

Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Literaturverweise

HM Zonderland.; EG Coerkamp.; J Hermans. Diagnosis of Breast Cancer: Contribution of US as an Adjunct to Mammography 1. Radiology. 1999 213 (2), 255-300.

M Kriege.; C Brekelmans.; C Boetes.; SH Muller. Differences between first and subsequent rounds of the MRISC breast cancer screening program for women with a familial or genetic predisposition. Cancer. 2006 106 (11), 2318-2326.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H332-H319

Harmful if swallowed. Harmful if inhaled. Causes serious eye irritation.

Sicherheitshinweise: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Merck
14,4616
Beilstein
178813
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
UV0175000

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