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(R)-(+)-1-Phenylethylamine is used as an intermediate in organic synthesis. It is also used to determine the enantiomeric purity of acids.
Both enantiomers are widely used resolving agent for chiral acids. They also find extensive use as chiral auxiliaries in asymmetric synthesis:
For use in the enantioselective synthesis of ɑ-amino nitriles and amino acids in the Strecker reaction, see: Chem. Ber., 110, 2098 (1977); J. Org. Chem., 48, 5369 (1983). Similarly, the preformed imines can be reacted with Trimethylsilyl cyanide, A19598: Chem. Lett., 331, 737 (1975). Enantioselective synthesis of cyclohexylamines from 2-alkylcyclohexanones via the imine and reduction: Tetrahedron Lett., 22, 2633 (1981); Chem. Ber., 117, 2076 (1984). Enantioselective synthesis of ɑ-aminoacetals from 1,1-dialkoxy-2-propanones: Synthesis, 608 (1989).
Selivanova, S. V.; Toscano, A.; Abate, C.; Berardi, F.; Müller, A.; Krämer, S. D.; Schibli, R.; Ametamey, S. M. Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging. Nucl. Med. Biol. 2015, 42 (4), 399-405.
Alvarado-Beltrán, I.; Maerten, E.; Toscano, R. A.; López-Cortés, J. G.; Baceiredo, A.; Álvarez-Toledano, C. Enantioselective synthesis of 4-alkenoic acids via Pd-catalyzed allylic alkylation: stereocontrolled construction of gamma and delta-lactones. Tetrahedron: Asymmetry 2015, 26 (15-16), 802-809.
Gefahrenhinweise (EU): H227-H302-H311-H314-H318
Combustible liquid. Harmful if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage.
Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.