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93102-05-7 - N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine, 94% - L19412 - Alfa Aesar

L19412 N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine, 94%

CAS-Nummer
93102-05-7
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 40,60
5g 125,00
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N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine, 94%

MDL
MFCD00674005
EINECS
000-000-0

Chemische Eigenschaften

Formel
C13H23NOSi
Molmasse
237.42
Siedepunkt
76°/0.3mm
Flammpunkt
66°(150°F)
Dichte
0.928
Brechungsindex
1.4920
Sensitivität
Moisture & Light Sensitive
Löslichkeit
Soluble in chloroform, ethyl acetate.

Anwendungen

N-Methoxymethyl-N-(trimethylsilylmethyl)benzylamine forms azomethine ylides which readily undergo [3+2] cycloaddition to α,ß-unsaturated esters affording N-benzyl substituted pyrrolidines in good yields. It reacts with asymmetric 1,3-dipolar cycloadditions in the practical, large-scale synthesis of chiral pyrrolidines. It is used in the the synthesis of 3-carboxy-1-azabicyclo[2.2.1]heptane derivatives, an important class of physiologically active compounds.

Bemerkungen

Moisture & Light Sensitive. Store away from oxidizing agents.

Literaturverweise

A. Stephen K. Hashmi; Dominic Riedel; Matthias Rudolph; Frank Rominger; Thomas Oeser. Regioselective Formation of Saturated Abnormal NHC-Gold(I) Complexes by [3+2] Cycloaddition of Azomethine Ylides and Isonitrile Gold(I) Complexes. Org. Biomol. Chem.2012, 18, 3827-3830.

Ultrasound treatment with LiF in acetonitrile generates an azomethine ylide which undergoes 1,3-dipolar cycloaddition to olefins to give pyrrolidine derivatives in good yield: J. Org. Chem., 52, 235 (1987). Also found use in the the synthesis of 3-carboxy-1-azabicyclo[2.2.1]heptane derivatives, an important class of physiologically active compounds: J. Org. Chem., 66, 2526 (2001).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P210u-P261-P280a-P305+P351+P338-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
4311216
Harmonized Tariff Code
2931.90
TSCA
No

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