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Lithiation with n-BuLi/LiOCH2CH2NMe2 takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP . It is a building block in heterocycle synthesis.
Vladimir I Tyvorskii.; Denis N Bobrov.; Oleg G Kulinkovich.; Kourosch Abbaspour Tehranib.; Norbert De Kimpe. Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines.Tetrahedron. 2001, 57 (10),2051-2055 .
Vladimir I Tyvorskii.; Denis N Bobrov.; Oleg G Kulinkovic.; Wim Aelterman.; Norbert De Kimpe. Synthesis of 3-(Trifluoromethyl)benzo[c][1,6]naphthyridines from Substituted 4H-Pyran-4-ones via 4-Amino-5-Aryl-2-(trifluoromethyl)pyridines.Tetrahedron. 2000, 56 (37),7313-7318 .
Lithiation with n-BuLi/LiOCH2CH2NMe2 takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP (see 2,2,6,6-Tetramethylpiperidine, A18712), 3-lithiation occurs: Eur. J. Org. Chem., 1569 (2003).
Gefahrenhinweise (EU): H226-H315-H319-H335
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