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269410-08-4 - 1H-Pyrazole-4-boronic acid pinacol ester, 98% - L19654 - Alfa Aesar

L19654 1H-Pyrazole-4-boronic acid pinacol ester, 98%

CAS-Nummer
269410-08-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 80,10
5g 286,00
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1H-Pyrazole-4-boronic acid pinacol ester, 98%

MDL
MFCD03453063

Chemische Eigenschaften

Formel
C9H15BN2O2
Molmasse
194.04
Schmelzpunkt
145-149°
Löslichkeit
Insoluble in water.

Anwendungen

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carboxylase inhibitors as well as other biologically active compounds.

Bemerkungen

Keep the container tightly sealed. Store in a cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literaturverweise

Peter R. Mullens. An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester and its corresponding lithium hydroxy ate complex: application in Suzuki couplings. Tetrahedron Letters. 2009, 50 (49), 6783-6786.

Jongwon Lim.; Brandon Taoka.; Ryan D Otte.; Kerrie Spencer.; Christopher J Dinsmore.; Michael D Altman.; Grace Chan.; Craig Rosenstein.; Sujata Sharma.; Hua-Poo Su.; Alexander A Szewczak.; Lin Xu.; Hong Yin, Joan Zugay-Murphy.; C Gary Marshall.; Jonathan R Young. Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. Journal of medicinal and pharmaceutical chemistry. 2011, 54 (20), 7334-7349.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2934.99
TSCA
No

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