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Ortho-lithiation with t-BuLi of the Boc-protected amine followed by addition of a Weinreb amide gave the 2-alkyl substituted 5-azaindole in good yield: J. Heterocycl. Chem., 29, 359 (1992), whereas DMF gave 6-azaindole in high yield: Synthesis, 877 (1996). 2-Substituted 6-azaindoles have also been synthesized in one step by direct dilithiation with s-BuLi, followed by reaction with an ester: J. Org, Chem., 70, 6512 (2005)./n
Gefahrenhinweise (EU): H301-H311-H315-H319-H335
Toxic if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed: Call a POISON CENTER or doctor/physician.