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58081-05-3 - (R)-(+)-beta-Hydroxy-gamma-butyrolactone, 90+%, ee 97+% - L20255 - Alfa Aesar

L20255 (R)-(+)-beta-Hydroxy-gamma-butyrolactone, 90+%, ee 97+%

CAS-Nummer
58081-05-3
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 61,90
5g 215,00
25g 836,00
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(R)-(+)-beta-Hydroxy-gamma-butyrolactone, 90+%, ee 97+%

MDL
MFCD00211248

Chemische Eigenschaften

Formel
C4H6O3
Molmasse
102.09
Siedepunkt
98-100°/0.3mm
Flammpunkt
>110°(230°F)
Dichte
1.302
Brechungsindex
1.4655
Löslichkeit
Miscible with ethanol and chloroform.

Anwendungen

(R)-(+)-β-Hydroxy-γ-butyrolactone is used in the pharmaceutical industry as a chiral building block for the statin class of cholesterol-reducing drugs. It is also used to prepare HIV inhibitors and nutritional supplement such as L-carnitine.

Bemerkungen

Store in a cool place. Incompatible with strong oxidizing agents.

Literaturverweise

Gade, N. R.; Iqbal, J. A Common Synthetic Protocol for the Cyclic and Acyclic Core of Migrastatin, Isomigrastatin, and Dorrigocin via a Chiral beta-Hydroxy-gamma-butyrolactone Intermediate. Eur. J. Org. Chem. 2014, 2014 (29), 6558-6564.

Blain, J. C.; Ricardo, A.; Szostak, J. W. Synthesis and Nonenzymatic Template-Directed Polymerization of 2'-Amino-2'-deoxythreose Nucleotides. J. Am. Chem. Soc. 2014, 136 (5), 2033-2039.

De Angelis, F.; De Fusco, E.; Desiderio, P.; Giannessi, F.; Piccirilli, F.; Tinti, M. O. Inversion of Configuration of (S)-beta-Hydroxy-gamma-butyrolactone with Total Retention of the Enantiomeric Purity. Eur. J. Org. Chem. 1999, 1999 (11), 2705-2707.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319

Causes skin irritation. Causes serious eye irritation.

Sicherheitshinweise: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Weitere Referenzen

Beilstein
3648447
Harmonized Tariff Code
2932.20
TSCA
No

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