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Benzimidazoles are bicyclic aromatic compounds, in which benzene is fused with an imidazole ring. Benzimidazole compounds play a vital role in the medicinal field having remarkable pharmacological activities such as antidiabetic, anticancer, antimicrobial and antiviral activity.
Historically, hydrazones were considered to have more chemotherapeutic value in the development of novel anti-microbial agents, but it was later found that a series of 1, 2-disubstituted-1Hbenzimidazole-N-alkylated-5-carboxamidine derivatives are much more potent antibacterial activities than hydrazones. Commercially, drugs, which have a benzimidazole backbone, have been deployed all over the global market for the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and the ZollingerûEllison syndrome.