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Benzofurazans (also known as 2,1,3-benzoxadiazoles) contain five-membered unsaturated ring structures fused to a benzene ring with two nitrogen atoms at the 1-,3- positions and one oxygen atom at 2- position in the five-membered ring.
Many benzoxadiazole derivatives have generated considerable interest among scientists as they have interesting biological activities. Some of these derivatives are utilized as useful anthiypertensive agents, analgesics and also are found to have antitubercular activity, antifungal activity, and anticancer activity. They are also important precursors for the synthesis of fluorescent oligomers and polymers that have small band gaps.
The N-oxide derivatives of benzofurazan, namely benzofuroxans, are used as synthetic precursors in the preparation of new biological compounds such as quinoxaline dioxide, benzimidazole, and phenazine derivatives. Benzofuroxans are employed in the synthesis of new biologically active compounds. These derivatives display antimycobacterial, anti-malarial, antileishmanial, and antituberculosis activity.