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Carbamyl chlorides, also referred to as carbamoyl chlorides, have the functional group R2NC(=O)Cl. When compared to acid chloride, these compounds are less sensitive hydrolytically largely due to the influence of amino group. Carbamoyl chlorides are useful reagents for the preparation of a number of agricultural compounds. For instance they are useful intermediates in the preparation of herbicides such as thiolcarbamate which involve their reaction with thiols. In the field of pharmaceuticals, N-ethyl-N-methylcarbamoyl chloride and N,N- diethylcarbamoyl chloride have been used in the preparation of parasympathomimetic and antifilarial drugs respectively, as intermediates. Besides pharmaceuticals, they also find application in the production of dyes and peroxides.
They are useful in organic synthesis in the preparation of a vast number of organic compounds such as 1,4-disubstituted 5-(4H)-tetrazolinones, imidazole derivatives, carbamates such as phenylcarbamates, unsymmetrical ureas, pyrrole-N-carbonyl compounds, O-allylic urethanes, carbonates, arylisocyanates, and N,N-dialkylcarbamate esters. In the field of biomolecular imaging, 4-morpholinecarbonyl chloride finds application in the preparation of fluorogenic labels.