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Being a potent anticancer agent that blocks DNA synthesis, the pharmaceutical compositions are used in chemotherapy. First member of platinum-containing anti-cancer drugs.
Dasari, S.; Tchounwou, P. B. Cisplatin in cancer therapy: Molecular mechanisms of action. European J. Pharmacol. 2014, 740, 364-378.
Kitagawa, R.; Katsumata, N.; Shibata, T.; Kamura, T.; Kasamatsu, T.; Nakanishi, T.; Nishimura, S.; Ushijima, K.; Takano, M.; Satoh, T.; Yoshikawa, H. Paclitaxel Plus Carboplatin Versus Paclitaxel Plus Cisplatin in Metastatic or Recurrent Cervical Cancer: The Open-Label Randomized Phase III Trial JCOG0505. J. Clin. Oncol. 2014, 58, 4391.
Hazard Statements: H300-H312+H332-H315-H318-H335-H350
Fatal if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. May cause cancer.
Precautionary Statements: P201-P202-P261-P264b-P270-P271-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P332+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant