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10471 cis-Diamminedichloroplatinum(II), Pt 64.5% min

CAS Number
15663-27-1
Synonyms
Cisplatin

Stock No. Size Price ($) Quantity Availability
10471-01 0.25g 108.00
10471-03 1g 344.00
10471-06 5g 1414.00
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cis-Diamminedichloroplatinum(II), Pt 64.5% min

MDL
MFCD00011623
EINECS
239-733-8

Chemical Properties

Formula
Cl2H6N2Pt
Formula Weight
300.06
Form
Micro Crystals
Melting point
270° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMF. Insoluble in most common solvents

Applications

Being a potent anticancer agent that blocks DNA synthesis, the pharmaceutical compositions are used in chemotherapy. First member of platinum-containing anti-cancer drugs.

Notes

Special handling precautions required. View MSDS prior to purchase. MSDS are available online at www.alfa.com

Literature References

Dasari, S.; Tchounwou, P. B. Cisplatin in cancer therapy: Molecular mechanisms of action. European J. Pharmacol. 2014, 740, 364-378.

Kitagawa, R.; Katsumata, N.; Shibata, T.; Kamura, T.; Kasamatsu, T.; Nakanishi, T.; Nishimura, S.; Ushijima, K.; Takano, M.; Satoh, T.; Yoshikawa, H. Paclitaxel Plus Carboplatin Versus Paclitaxel Plus Cisplatin in Metastatic or Recurrent Cervical Cancer: The Open-Label Randomized Phase III Trial JCOG0505. J. Clin. Oncol. 2014, 58, 4391.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H312+H332-H315-H318-H335-H350

Fatal if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. May cause cancer.

Precautionary Statements: P201-P202-P261-P264b-P270-P271-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P332+P313-P362-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2317
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2843.90
TSCA
Yes
RTECS
TP2450000

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