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14913-33-8 - trans-Diamminedichloroplatinum(II), Pt 64.5% min - Dichlorodiammineplatinum(II) - Transplatin - 10472 - Alfa Aesar

10472 trans-Diamminedichloroplatinum(II), Pt 64.5% min

CAS Number
14913-33-8
Synonyms
Dichlorodiammineplatinum(II)
Transplatin

Size Price ($) Quantity Availability
0.25g 48.40
1g 160.00
5g 710.00
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trans-Diamminedichloroplatinum(II), Pt 64.5% min

MDL
MFCD00011623
EINECS
238-980-9

Chemical Properties

Formula
Cl2H6N2Pt
Formula Weight
300.06
Form
Crystalline
Melting point
340° dec.
Solubility
Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.

Applications

trans-Diamminedichloroplatinum(II) acts as a reversible RNA-protein cross-linking agent. It is also used in plating baths. It reacts with DNA after hydrolysis to get both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA.

Notes

Incompatible with strong oxidizing agents.

Literature References

Tsotsoros, S. D.; Qu, Y.; Farrell, N. P. The reaction of dichlorodiammineplatinum(II), [PtCl2(NH3)2], isomers with zinc fingers. J. Inorg. Biochem. 2015, 143, 117-122.

Wang, Y.; Benzina, A.; Molin, D. G. M.; Akker, N. V. D.; Gagliardi, M.; Koole, L. H. Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy. J. Biomater. Sci., Polym. Ed. 2015, 26 (2), 77-91.

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H315-H319-H317-H341-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause respiratory irritation.

Precautionary Statements: P261-P262-P280h-P305+P351+P338-P308+P313

Avoid breathing dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention.

Other References

Harmonized Tariff Code
2843.90
TSCA
No
RTECS
TP2455000

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