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trans-Diamminedichloroplatinum(II) acts as a reversible RNA-protein cross-linking agent. It is also used in plating baths. It reacts with DNA after hydrolysis to get both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA.
Tsotsoros, S. D.; Qu, Y.; Farrell, N. P. The reaction of dichlorodiammineplatinum(II), [PtCl2(NH3)2], isomers with zinc fingers. J. Inorg. Biochem. 2015, 143, 117-122.
Wang, Y.; Benzina, A.; Molin, D. G. M.; Akker, N. V. D.; Gagliardi, M.; Koole, L. H. Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy. J. Biomater. Sci., Polym. Ed. 2015, 26 (2), 77-91.
Hazard Statements: H301+H311+H331-H317-H318-H334-H340-H351
Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. May cause an allergic skin reaction. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause genetic defects. Suspected of causing cancer.
Precautionary Statements: P201-P202-P264b-P270-P271-P272-P280g-P281-P285-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P311-P312-P330-P333+P313-P361-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation or rash occurs: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant