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10472 trans-Diamminedichloroplatinum(II), Pt 64.5% min

CAS Number
14913-33-8
Synonyms
Dichlorodiammineplatinum(II)
Transplatin

Stock No. Size Price ($) Quantity Availability
10472-01 0.25g 51.70
10472-03 1g 169.00
10472-06 5g 740.00
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trans-Diamminedichloroplatinum(II), Pt 64.5% min

MDL
MFCD00011623
EINECS
238-980-9

Chemical Properties

Formula
Cl2H6N2Pt
Formula Weight
300.06
Form
Crystalline
Melting point
340° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.

Applications

trans-Diamminedichloroplatinum(II) acts as a reversible RNA-protein cross-linking agent. It is also used in plating baths. It reacts with DNA after hydrolysis to get both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA.

Notes

Incompatible with strong oxidizing agents.

Literature References

Tsotsoros, S. D.; Qu, Y.; Farrell, N. P. The reaction of dichlorodiammineplatinum(II), [PtCl2(NH3)2], isomers with zinc fingers. J. Inorg. Biochem. 2015, 143, 117-122.

Wang, Y.; Benzina, A.; Molin, D. G. M.; Akker, N. V. D.; Gagliardi, M.; Koole, L. H. Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy. J. Biomater. Sci., Polym. Ed. 2015, 26 (2), 77-91.

GHS Hazard and Precautionary Statements

Hazard Statements: H301+H311+H331-H317-H318-H334-H340-H351

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. May cause an allergic skin reaction. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause genetic defects. Suspected of causing cancer.

Precautionary Statements: P201-P202-P264b-P270-P271-P272-P280g-P281-P285-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P311-P312-P330-P333+P313-P361-P363-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation or rash occurs: Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2843.90
TSCA
No
RTECS
TP2455000

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