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It is used as a catalyst in certain organic transformations like synthesis of ynamides. It is used in Fehling's solution and Benedict's solution for testing reducing sugars, in the Biuret reagent for testing proteins, and in combination with potassium permanganate for testing blood for anemia. It is used in the preparation of Cheshunt compound for horticulture. It finds use as a coloring ingredient in artworks, as an oxidant in combination with potassium permanganate for oxidizing primary alcohols, and as a mordant in dyeing. It is used to etch copper or zinc plates for intaglio print making.
Ruggiero, M. T.; Bardon, T.; Strlič, M.; Taday, P. F.; Korter, T. M. Assignment of the Terahertz Spectra of Crystalline Copper Sulfate and Its Hydrates via Solid-State Density Functional Theory. J. Phys. Chem. A 2014, 118 (43), 10101-10108.
Chiar, Y.; Glaberman, S.; Serén, N.; Carretero, M. A.; Capellini, I. Phylogenetic signal in amphibian sensitivity to copper sulfate relative to experimental temperature. Eco. Appl. 2015, 25 (3), 592-602.
Zhang, Y.; Hsung, R. P.; Tracey, M. R.; Kurtz, K. C. M.; Vera, E. L. Copper Sulfate-Pentahydrate-1,10-Phenanthroline Catalyzed Amidations of Alkynyl Bromides. Synthesis of Heteroaromatic Amine Substituted Ynamides. Org. Lett. 2004, 6 (7), 1151-1154.
Espinosa, E.; Meyer, M.; Berard, D.; Guilard, R. [(1,4,8,11-Tetraazacyclotetradeca-1,4,8,11-tetrayl)tetraacetamide-6N1,N4,N8,N11,O1,O8]copper(II) sulfate 4.5-hydrate. Acta Crystallogr. C 2002, C58, m119-m121.
Hazard Statements: H302-H313-H315-H319
Harmful if swallowed. May be harmful in contact with skin. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P260-P273-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Dispose of contents/container in accordance with local/regional/national/international regulations.