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It is used in electroplating and as a catalyst for organic conversions, for example in chemo-selective thioacetalization of aldehydes. In combination with lithium aluminum hydride, it serves as a reducing agent for alkenes, alkynes, and organic halides; it can cleave N-O bond and open epoxides. It is a precursor to several nickel-phosphine complexes, such as bis(triphenylphosphine)nickel(II) chloride, which are used in alkyne trimerizations, carbonylations, and as catalysts in organic reactions such as Suzuki-Miyaura cross coupling reactions as an alternative to palladium(0) catalysts. It is the precursor to acetylacetonate complex of Ni, used for producing 1,5-cyclooctadiene complex, an important reagent in organonickel chemistry. It can be used to prepare the sandwich compound nickelocene through dimethoxyethane complex of nickel chloride.
Topal, A.; Atamanalp, M.; Oruç, E.; Halıcı, M. B.; Şişecioğlu, M.; Erol, H. S.; Gergit, A.; Yılmaz, B. Neurotoxic effects of nickel chloride in the rainbow trout brain: Assessment of c-Fos activity, antioxidant responses, acetylcholinesterase activity, and histopathological changes. Fish Physiol. Biochem. 2015, 41 (3), 625-634.
Vignarooban, K.; Dissanayake, M. A. K. L.; Albinsson, I.; Mellander, B.-E. Ionic conductivity enhancement in PEO:CuSCN solid polymer electrolyte by the incorporation of nickel-chloride. Solid State Ionics 2015, 278, 177-180.
Khan, A. T.; Mondal, E.; Sahu, P. R.; Islam, S. Nickel(II) chloride as an Efficient and Useful Catalyst for Chemoselective Thioacetalization of Aldehydes. Tetrahedron Lett. 2003, 44 (5), 919-922.
Zhao, W.; Wu, J.; Cao, S. Highly Efficient Nickel(II) Chloride/ Bis(tricyclohexylphosphine)nickel(II) Chloride-Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride. Adv. Synth. Catal. 2012, 354 (4), 574-578.
Hazard Statements: H301-H331-H315-H334-H317-H341-H350-H360-H372
Toxic if swallowed. Toxic if inhaled. Causes skin irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause cancer. May damage fertility or the unborn child. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P201-P273-P309+P311
Obtain special instructions before use. Avoid release to the environment. IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.