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Phosphorus(V) oxychloride is widely used as a dehydrating agent and a chlorinating agent. Useful for the conversion of amide to nitriles, in Bischler-Napieralski reactions, Vilsmeier Haak reaction, and other reactions producing commercially important intermediates. Acts a source of liquid phosphorus in semiconductor industry. Manufacture of trialkyl phosphate esters and triarylphosphate esters, including commercially popular tricresyl phosphate,which is useful as a plasticizer, flame retardant, gasoline additive, hydrolytic fluid, etc...
Farzipour, S.; Saeedi, M.; Mahdavi, M.; Yavari, H.; Mirzahekmati, M.; Ghaemi, N.; Foroumadi, A.; Shafiee, A. An Efficient Reagent for the Transformation of 2-Amino benzamides into Quinazolin-4(3h)-one Derivatives. Syn. Commun. 2014, 44, 481-487.
Brenek, S. J.; am Ende, D. J.; Clifford, P. J. Phosphorus Oxychloride and Acetone:? An Incompatibility Investigation Using ARC. Org. Proc. Res. Dev. 2000, 4 (6), 585-586.
Hazard Statements: H302-H330-H314-H372
Harmful if swallowed. Fatal if inhaled. Causes severe skin burns and eye damage. Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements: P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.