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Oxidation, catalyst in Sharpless dihydroxylations Osmium(VIII) oxide is used in the Sharpless oxyamination to give vicinal amino-alcohols. It is used to oxidize alkenes to the vicinal diols. It acts as a staining agent used in transmission electron microscopy to provide contrast to the image and as a stain for lipids in optical microscopy. As a polymer stain, it is also used to stain selectively copolymers especially styrene-butadiene block copolymers. Further, it is involved in the synthesis of Isosteviol.
Gally, C.; Nestl, B. M.; Hauer, B. Engineering Rieske Non-Heme Iron Oxygenases for the Asymmetric Dihydroxylation of Alkenes. Angew. Chem. Int. Ed. 2015, 54 (44), 12952-12956.
Cheng, W.; Kumar, J. N.; Zhang, Y.; Liu, Y. pH-and redox-responsive self-assembly of amphiphilic hyperbranched poly(amido amine)s for controlled doxorubicin delivery. Biomater. Sci. 2015, 3 (4), 597-607.
Hazard Statements: H300-H310-H330-H314
Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage.
Precautionary Statements: P260u-P201-P280h-P304+P340-P405-P501a
Obtain special instructions before use. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.