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Tetra-n-butylammonium chloride hydrate is used with phosphorus pentoxide for greener deoxychlorination. It is used as a phase transfer catalyst for the preparation of 2-(3-pyridyl)-1-methylpyrrole by the reaction between 3-bromopyridine and 1-methyl-2pyrrolecarboxylic acid.
Kobori, T.; Muromachi, S.; Yamasaki, T.; Takeya, S.; Yamamoto, Y.; Alavi, S.; Ohmura, R. Phase Behavior and Structural Characterization of Ionic Clathrate Hydrate Formed with Tetra-n-butylphosphonium Hydroxide: Discovery of Primitive Crystal Structure. Cryst. Growth Des. 2015, 15 (8), 3862-3867.
Sun, Z. G.; Liu, C. G. Equilibrium conditions of methane in semiclathrate hydrates of tetra-n-butylammonium chloride. J. Chem. Eng. Data 2012, 57 (3), 978-981.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant