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22905 Pyridine, HPLC Grade, 99.5+%

CAS Number
110-86-1
Synonyms

Stock No. Size Price ($) Quantity Availability
22905-K2 1L 142.00
22905-K7 4L 395.00
22905-M1 *4x1L 473.00
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Pyridine, HPLC Grade, 99.5+%

MDL
MFCD00011732
EINECS
203-809-9

Chemical Properties

Formula
C5H5N
Formula Weight
79.10
Form
Liquid
Melting point
-42°
Boiling Point
115°
Flash Point
20°(68°F)
Density
0.978
Refractive Index
1.5100
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with water, alcohol, ether, pet ether, and oils.

Grade Specifications

Maximum level of impurities: Evaporation residue 4ppm, H2O 0.05%

Applications

Pyridine is used as a mobile phase in High Performance Liquid Chromatography and Liquid Chromatography coupled with Mass Spectrometry

Notes

Filtered through 0.2µ filters. Suitable for spectrophotometry, chromatography.Pyridine is stable under normal temperatures and pressures. It is incompatible with strong oxidizing agents, and acids.

Literature References

Baumann, M.; Baxendale I. R. An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles. Beilstein J. Org. Chem. 2013, 9, 2265-2319.

Bull, J. A.; Mousseau, J. J.; Pelletier, G.; Charette, A. B. Synthesis of pyridine and dihydropyridine derivatives by regio- and stereoselective addition to N-activated pyridines. Chem. Rev. 2012, 112 (5), 2642-2713.

Widely used as a base and nucleophilic catalyst in acylations, sulfonylations, etc. See also 4-(Dimethyl­amino)­pyridine, A13016.

Reacts with thionyl chloride to give N-(4-pyridyl)pyridinium chloride hydrochloride, a useful intermediate for the preparation of 4-substituted pyridines by nucleophilic displacement. Thus, reaction with sulfite ion gives the sulfonate: Org. Synth. Coll., 5, 977 (1973). Similarly, pyridine can be activated to substitution at the 4-position by reaction with Ethyl­ chloroformate, L06311, or tert-Butyl­dimethyl­silyl­ trifluoromethanesulfonate, A12174. The acyl or silyl pyridinium salt then reacts with Grignards or organocuprates, to give 4-substituted dihydropyridines which can readily be rearomatized: Bull. Chem. Soc. Jpn., 57, 1994 (1984).

For use in Cr(VI) oxidation reactions, see Chromium(VI)­ oxide, 12522.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H302+H312+H332-H315-H319

Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P264b-P270-P271-P280-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P312-P330-P332+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,7970
Beilstein
103233
Hazard Class
3
Packing Group
II
Harmonized Tariff Code
2933.31
TSCA
Yes
RTECS
UR8400000

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