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30387 Tricyclohexylphosphine oxide

CAS Number
13689-19-5
Synonyms

Stock No. Size Price ($) Quantity Availability
30387-03 1g 36.60
30387-06 5g 126.00
30387-14 25g 453.00
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Tricyclohexylphosphine oxide

MDL
MFCD00014298

Chemical Properties

Formula
(C6H11)3P(O)
Formula Weight
296.42
Form
Crystalline
Melting point
155-157°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in most organic solvents. Insoluble in water.

Applications

Tricyclohexylphosphine oxide is used as a ligand for a range of metal-catalyzed organic transformations. Ligand used in the Pd-catalyzed coupling of malononitrile with aryl halides.1 Bulky phosphine ligand used with a Pd(0)-triolefinic macrocycle catalyst for Suzuki coupling of aryl bromides and chlorides. This ligand is applied with Ni as a key intermediate in the formation of cylcopentane compounds.

Notes

Keep container tightly closed. Store away from oxidizing agents, stored indefinitely under an inert atmosphere in a tightly sealed container in a cool, dry location.

Literature References

Anthony D. Piscopio.; John F. Miller.; Kevin Koch. Solid phase heterocyclic synthesis via ring closing metathesis: Traceless linking and cyclative cleavage through a carbon-carbon double bond. Tetrahedron Letters. 1997, 38, (41), 7143-7146.

Vladimir V. Grushin.; Corinne Bensimon.; Howard Alper. Dichlorobis(tricyclohexylphosphine)palladium(II): Synthesis and Crystal Structure. An Exceptionally Simple and Efficient Preparation of Bis(tricyclohexylphosphine)palladium(0). Inorg. Chem. 1994, 33, (21), 4804-4806.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2931.39
TSCA
No

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