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30394 Trimethylphosphine oxide

CAS Number

Stock No. Size Price ($) Quantity Availability
30394-03 1g 92.60
30394-06 5g 297.00
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Trimethylphosphine oxide


Chemical Properties

Formula Weight
Melting point
Storage & Sensitivity
Ambient temperatures.
Soluble in polar organic solvents.


Trimethylphosphine oxide is a common side product in organic synthesis, including the Wittig, Staudinger, Mitsunobu reactions and also in the manufacture of triphenylphosphine. It is a popular reagent to induce the crystallization of various chemical compounds. It acts as an excellent ligand for hard metal centers. It can react with 9-methyl-9-azonianthracene methyl sulfate to get (10-methyl-9,10-dihydro-acridin-9-yl)-phosphonic acid dimethyl ester using sodium iodide and acetonitrile as solvent.


Incompatible with oxidizing agents.

Literature References

Hu, Y.; Guo, B.; Fu, Y.; Ren, Y.; Tang, G.; Chen, X.; Yue, B.; He, H. Facet-dependent acidic and catalytic properties of sulfated titania solid superacids. Chem. Commun. 2015, 51 (75), 14219-14222.

Hérault, D.; Nguyen, D. H.; Nuel, D.; Buono, G. Reduction of secondary and tertiary phosphine oxides to phosphines. Chem. Soc. Rev. 2015, 44 (8), 2508-2528.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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