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31801 Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)

CAS Number
77-86-1
Synonyms
2-Amino-2-hydroxymethyl-1,3-propanediol
TRIS

Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)

MDL
MFCD00004679
EINECS
201-064-4

Chemical Properties

Formula
(HOCH2)3CNH2
Formula Weight
121.14
Form
Crystalline
Melting point
171-172°
Boiling Point
219-220°/10mm
Density
1.353
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Soluble in water, ethylene glycol, methanol, ethanol, dimethyl formamide, acetone, ethyl acetate, olive oil, chloroform and alkaline solution.

Grade Specifications

Maximum level of impurities: Absorbance P.T., H2O 2.0%, Insoluble matter 0.005%, Heavy Metals (as Pb) 5ppm, Fe 5ppm

Applications

Tris(hydroxymethyl)aminomethane is used as a buffer in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis. It acts as a precursor for the preparation of polymers, oxazolones and oxazolidines.

Notes

Hygroscopic. Incompatible with bases and strong oxidizing agents.

Literature References

Gharamaleki, V. J; Gharamaleki, K. J.; Soleymani, J.; Acree Jr, W. E.; Kenndler, E.; Jouyban, A. Solubility of Tris (hydroxymethyl) aminomethane in Water+ Methanol+ 1-Propanol Mixtures at Various Temperatures. J. Chem. Eng. Data 2015, 60 (8), 2515-2520.

Devi, M.; Dhir, A.; Pradeep, C. P. A Tris (hydroxymethyl) aminomethane-Rhodamine Spirolactam Derivative as Dual Channel pH and Water Sensor and Its Application to Bio Imaging. Eur. J. Org. Chem. 2015, 2015 (21), 4650-4657.

Other References

Merck
14,9772
Beilstein
741883
Harmonized Tariff Code
2922.19
TSCA
Yes
RTECS
TY2900000

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