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33505 Sodium bis(trimethylsilyl)amide, 98%

CAS Number
1070-89-9
Synonyms
Sodium hexamethyldisilazane
N-Sodiohexamethyldisilazane

Stock No. Size Price ($) Quantity Availability
33505-04 2g 16.10
33505-09 10g 58.50
33505-18 50g 225.00
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Sodium bis(trimethylsilyl)amide, 98%

MDL
MFCD00009835
EINECS
213-983-8

Chemical Properties

Formula
C6H18NNaSi2
Formula Weight
183.38
Form
Crystalline
Melting point
171-175°
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Soluble in hexane, toluene, ether,terahydrofuran, benzene and toluene.

Applications

Sodium bis(trimethylsilyl)amide is used as a base in organic synthesis as well as to deprotonate other compounds containing weakly acidic O-H, S-H, and N-H bonds. It is used to prepare amines by reacting with alkyl halides. It finds application in certain organic reactions viz. generation of carbenes by dehydrohalogenation of halocarbons and Wittig reagents by deprotonation of phosphonium salts. It accelerates the polymerization of pheneylacetylene in conjunction with rhodium(I) catalysis. Furthermore, it is used for the preparation of lanthanide complexes.

Notes

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents, strong acids and moisture.

Literature References

Lis, A. V.; Tsyrendorzhieva, I. P.; Albanov, A. I.; Rakhlin, V. I.; Voronkov, M. G. Migration of trimethylsilyl group in the reaction of sodium bis (trimethylsilyl) amide with bromobenzene. Russ. J. Org. Chem. 2013, 49 (10), 1451-1453.

Zhang, T.; Barclay, L.; Walensky, L. D.; Saghatelian, A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. J. Lipid Res. 2015, 56 (8), 1501-1510.

GHS Hazard and Precautionary Statements

Hazard Statements: H228-H261-H314-H335-H500

Flammable solid. In contact with water releases flammable gas. Causes severe skin burns and eye damage. May cause respiratory irritation. May form combustible dust concentrations in air

Precautionary Statements: P210-P231+P232-P240-P241-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Handle under inert gas. Protect from moisture. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
8
Packing Group
I
Harmonized Tariff Code
2931.90
TSCA
Yes

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