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36239 Aluminon, ACS

CAS Number
569-58-4
Synonyms
Aurintricarboxylic acid triammonium salt

Stock No. Size Price ($) Quantity Availability
36239-14 25g 40.60
36239-22 100g 122.00
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Aluminon, ACS

MDL
MFCD00040925
EINECS
209-319-1

Chemical Properties

Formula
C22H23N3O9
Formula Weight
473.44
Form
Powder
Melting point
220-225° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water(800g/L).

Grade Specifications

Maximum level of impurities: Insoluble matter 0.1%, Residue after ignition 0.2%, Sensitivity to aluminum P.T.

Applications

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

R G González,; R S Haxo,; T Schleich. Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions. Biochemistry (Washington). 1980, 19 (18),4299-4303.

Y Benchokroun,; J Couprie,; A K Larsen. Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. Biochemical Pharmacology. 1995, 49(3), 305-313.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362

Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse.

Other References

Merck
14,322
Harmonized Tariff Code
2918.99
TSCA
Yes
RTECS
GU4800000

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