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40526 N-Ethylmaleimide, 99+%

CAS Number
128-53-0
Synonyms
1-Ethyl-1H-pyrrole-2,5-dione
NEM

Stock No. Size Price ($) Quantity Availability
40526-03 1g 20.20
40526-06 5g 41.00
40526-14 25g 140.00
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N-Ethylmaleimide, 99+%

MDL
MFCD00005509
EINECS
204-892-4

Chemical Properties

Formula
C6H7NO2
Formula Weight
125.13
Form
Crystalline
Melting point
43-46°
Boiling Point
209-211°
Flash Point
73°(163°F)
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in ethanol, water, chloroform, methanol and toluene.

Applications

N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.

Notes

Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, strong acids and strong bases.

Literature References

Shah, N.; Colbert, K. N.; Enos, M. D.; Herschlag, D.; Weis, W. I. Three alpha-SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF). J. Biol. Chem. 2015, 290 (4), 2175-2188.

Iwasaki, F.; Suga, K.; Umakoshi, H. Pseudo-Interphase of Liposome Promotes 1, 3-Dipolar Cycloaddition Reaction of Benzonitrile Oxide and N-Ethylmaleimide in Aqueous Solution. J. Phys. Chem. B 2015, 119, (30), 9772-9779.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H311-H314-H317-H335

Fatal if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P270-P271-P272-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3822
Beilstein
112448
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2925.19
TSCA
Yes
RTECS
UX9625000

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