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3-(Benzyl amino)propionitrile was used as starting reagent in the synthesis of (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid, 3-[benzyl-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-propionitrile. It undergoes aza-type Michael reaction with 1-hydroxymethyl-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester under mild conditions
Atsushi Ohigashi; Takashi Kikuchi and Shunsuke Goto. A Practical and Efficient Synthesis of (3R,4S)-1-Benzyl-4-phenylpyrrolidine-3-carboxylic acid via an Aziridinium Ion Intermediate. Org. Process Res. Dev. 2010, 14, (1), 127-132.
Herrag, Leila; Touzani, Rachid; Ramdani, Abdelkrim; Hammouti, Belkheir. 3-[Benzyl-(1, 5-dimethyl-1H-pyrazol-3-ylmethyl)-amino]-propionitrile. Molbank. 2006, 5, M496.
Hazard Statements: H302+H312+H332
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statements: P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P312-P330-P363-P501c
Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant