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42374 Chloramine-T trihydrate, ACS, 98.0-103.0%

CAS Number
7080-50-4
Synonyms

Stock No. Size Price ($) Quantity Availability
42374-22 100g 31.50
42374-36 500g 91.30
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Chloramine-T trihydrate, ACS, 98.0-103.0%

MDL
MFCD00149066
EINECS
204-854-7

Chemical Properties

Formula
CH3C6H4SO2N(Cl)Na•3H2O
Formula Weight
281.69 (227.67anhy)
Form
Crystalline
Melting point
167-170°
Flash Point
192°(377°F)
Storage & Sensitivity
Moisture Sensitive. Store under Argon. Ambient temperatures.
Solubility
Soluble in water and ethyl alcohol. Insoluble in benzene and ethers.

Applications

Reagent for selective oxidation of methionineChloramine-T trihydrate is used as an intermediate in the manufacture of chemical substances such as pharmaceuticals. It combines with iodogen or lactoperoxidase and is commonly used for labeling peptides and proteins with radioiodine isotopes. Hypochlorite released from chloramine-T acts as an effective oxidizing agent for iodide to form iodine monochloride (ICl).

Notes

Incompatible with strong oxidizing agents, acids and ammonia.

Literature References

Mal, S.; Prathap, K. J.; Smith, S. C.; Umarye, J. D. Facile one pot synthesis of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazines via oxidative cyclisation using chloramine T. Tetrahedron Lett. 2015, 56 (22), 2896-2901.

Dzandzi, J. P. K.; Vera, D. R. B.; Genady, A. R.; Albu, S. A.; Eltringham-Smith, L. J.; Capretta, A.; Sheffield, W. P.; Valliant, J. F. Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination, and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis. J. Org. Chem. 2015, 80 (14), 7117-7125.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H314-H334-H335

Harmful if swallowed. Causes severe skin burns and eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P270-P271-P280-P285-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2075
Beilstein
3924168
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2935.90
TSCA
Yes
RTECS
XT5616800

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