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Diisobutylaluminum hydride is used as a reducing agent in organic chemistry. It is also used to reduce alpha-beta unsaturated esters to the corresponding allylic alcohol to ester, acyl chlorides to alcohols and nitriles to amines. It acts as an electrophilic reducing agent. It finds application in the palladium -catalyzed debromination of secondary alkyl bromides and ring opening of perbenzylated furaosides. Further, it acts as a co-catalyst for the polymerization of alkenes.
Ishmuratov, G. Y.; Vydrina, V. A.; Galkina, Y. A.; Yakovleva, M. P.; Kravchenko, A. A.; Muslukhov, R. R.; Tolstikov, A. G. Low-temperature reduction of acyclic (-)-mentholactone derivatives with diisobutylaluminum hydride in methylene chloride. Russ. J. Org. Chem. 2015, 51 (7), 947-950.
Sugimoto, R.; Matsugi, T. Direct Incorporation of Hydroxy Groups into Isotactic Polypropylene via Metallocene-Catalyzed Copolymerization of Ester Group Containing Vinyl Monomer Treated with Dialkylaluminum Hydride and Propylene. Bull. Chem. Soc. Jpn. 2015, 88 (9), 1238-1240.
Hazard Statements: H224-H260-H302-H333-H314-H318-H361-H336-H373-H304
Extremely flammable liquid and vapour. In contact with water releases flammable gases which may ignite spontaneously. Harmful if swallowed. May be harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways.
Precautionary Statements: P223-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from any possible contact with water, because of violent reaction and possible flash fire. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.