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Reagent for precipitation of proteins5-Sulfosalicylic acid dihydrate is used as a metal scavenger and it forms proton-transfer dye complexes with diazo compounds such as 4-(phenyldiazenyl)aniline. It is employed as a preparative measure for removing proteins prior to chromatographic analysis. It plays a vital role in reducing and fixation of proteins in agarose and polyacrylamide gels. It acts as a surfactant and lubricating grease additive. It is also used in urine tests to determine urine protein content. Further, it acts as an intermediate in the synthesis of active pharmaceutical ingredients like doxycycline and methacycline. In addition to this, it is used as a spray reagent for the detection of amino acids on thin layer chromatography (TLC) plates and as a doping agent for polyaniline.
Cui, M.; Lin, H.; Wang, X.; Cao, L.; Sui, J. 5-sulfosalicylic Acid Dihydrate-Based Pretreatment for the Modification of Enzyme-Linked Immunoassay of Fluoroquinolones in Fishery Products. J. Immunoassay Immunochem. 2015, 36 (5), 517-531.
Jin, W.; Huang, P.; Wu, F.; Ma, L. H. Ultrasensitive colorimetric assay of cadmium ion based on silver nanoparticles functionalized with 5-sulfosalicylic acid for wide practical applications. Analyst 2015, 140 (10), 3507-3513.
Hazard Statements: H302-H314-H318
Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.