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Dimethylsuberimidate dihydrochloride is used as a homobifunctional cross-linking reagent for amino groups. It is also used for the modification of tyrosinase to produce biocatalytic enzymatic flow-through detectors. It serves as a cross-linker for preparation of collagen-calcium phosphate composites. Further, it is used in the treatment of avian myeloblastosis virus.
King, M. J.; Jepson, M. A.; Guest, A.; Mushens, R. Detection of hereditary pyropoikilocytosis by the eosin-5-maleimide (EMA)-binding test is attributable to a marked reduction in EMA-reactive transmembrane proteins. Int. J. Lab. Hematol. 2011, 33 (2), 205-211.
Suzuki, C.; Yun, C. S.; Umeda, T.; Terabayashi, T.; Watanabe, K.; Yamane, H.; Nojiri, H. Oligomerization and DNA-binding capacity of Pmr, a histone-like protein H1 (H-NS) family protein encoded on IncP-7 carbazole-degradative plasmid pCAR1. Biosci. Biotechnol. Biochem. 2011, 75 (4), 711-717.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.