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5-Hexyn-1-ol is used as starting material for the preparation of terminal alkynes and lactones containing terminal alykyne groups. It is also used in the synthesis of cinnoline-fused cyclic enediyne, llycopodium alkaloids, (+)-nankakurine A and (+)-nankakurine B and 7-benzoyloxy-3-(2-nitrophenylseleno)-1,5-cyclodecadiyne.
Bellina, F.; Lessi, M.; Marianetti, G.; Panattoni, A. Highly regioselective C-5 alkynylation of imidazoles by one-pot sequential bromination and Sonogashira cross coupling. Tetrahedron Lett. 2015, 56 (25), 3855-3857.
Park, H. J.; Kim, J. E.; Yum, E. K.; Kim, Y. H.; Han, C. W. Copper- and Ligand-free Heteroannulation of o-Halohydroxypyridine with Terminal Alkynes Using Pd/C Catalyst: One-Pot Synthesis of 2-Substituted Furopyridines and their Functionalization. Bull. Korean Chem. Soc. 2015, 36 (1), 211-218.
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.