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43792 Ethyl 2-cyanoacetoacetate

CAS Number
634-55-9
Synonyms
Ethyl 2-acetylcyanoacetate

Stock No. Size Price ($) Quantity Availability
43792-04 2g 52.80
43792-09 10g 191.00
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Ethyl 2-cyanoacetoacetate

MDL
MFCD00043487

Chemical Properties

Formula
C2H5OOCCH(CN)COCH3
Formula Weight
155.16
Form
Liquid
Storage & Sensitivity
Ambient temperatures.
Solubility
Not miscible or difficult to mix in water.

Applications

It is used as a pharmaceutical intermediate. It is also used in the synthesis of fluorine-containing alkyl 2-cyano-3-oxocarboxylates and also in the syntheses of pyrazolo [1, 2-a] pyrazole and pyrazolo [5, 1-b] [1, 3] oxazine derivatives.

Notes

Product exists as a 1:2 keto:enol tautomer mixture

Literature References

Gustav E. Lienhard, et al. The Reaction of Carbanions with N,S-Diacetylcysteamine. A Model for Enzymatic Carbon-Carbon Condensation.J. Am. Chem. Soc., 1965,87(17), 3863-3874.

Matthieu Desroses, et al. A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P®) Mediated One-Pot Pyrazolone Synthesis.Eur. J. Org. Chem.,2013,2013 (26), 5879-5885.

GHS Hazard and Precautionary Statements

Hazard Statements: H301+H311-H330

Toxic if swallowed. Toxic in contact with skin. Fatal if inhaled.

Precautionary Statements: P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P310-P312-P330-P361-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2926.90
TSCA
No

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