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43792 Ethyl 2-cyanoacetoacetate

CAS Number
634-55-9
Synonyms
Ethyl 2-acetylcyanoacetate

Stock No. Size Price ($) Quantity Availability
43792-04 2g 55.00
43792-09 10g 201.00
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Ethyl 2-cyanoacetoacetate

MDL
MFCD00043487

Chemical Properties

Formula
C2H5OOCCH(CN)COCH3
Formula Weight
155.16
Form
Liquid
Storage & Sensitivity
Ambient temperatures.
Solubility
Not miscible or difficult to mix in water.

Applications

It is used as a pharmaceutical intermediate. It is also used in the synthesis of fluorine-containing alkyl 2-cyano-3-oxocarboxylates and also in the syntheses of pyrazolo [1, 2-a] pyrazole and pyrazolo [5, 1-b] [1, 3] oxazine derivatives.

Notes

Product exists as a 1:2 keto:enol tautomer mixture

Literature References

Gustav E. Lienhard, et al. The Reaction of Carbanions with N,S-Diacetylcysteamine. A Model for Enzymatic Carbon-Carbon Condensation.J. Am. Chem. Soc., 1965,87(17), 3863-3874.

Matthieu Desroses, et al. A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P®) Mediated One-Pot Pyrazolone Synthesis.Eur. J. Org. Chem.,2013,2013 (26), 5879-5885.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H331

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.

Precautionary Statements: P261-P280h-P301+P310a-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2926.90
TSCA
No

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  • A15641

    Ethyl 4-chloroacetoacetate, 97%
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    4-Nitrobenzenesulfonyl chloride, 97%

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