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43928 N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal™ bottles

CAS Number
25561-30-2
Synonyms

Stock No. Size Price ($) Quantity Availability
43928-06 5g 38.90
43928-14 25g 113.00
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N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal™ bottles

MDL
MFCD00008269
EINECS
247-103-9

Chemical Properties

Formula
C8H18F3NOSi2
Formula Weight
257.40
Form
Liquid
Melting point
-10°
Boiling Point
145-147°
Flash Point
23°(73°F)
Density
0.97
Refractive Index
1.3840
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Store under Nitrogen.
Solubility
Soluble in water (hydrolyses), chloroform and hexane.

Applications

N,O-Bis(trimethylsilyl)trifluoroacetamide is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides.

Notes

Store at 4°C. Keep cool and dry in tightly closed container. Protect from heat and moisture. Store away from oxidizing agents.

Literature References

Ali Shareef,; Craig J Parnis,; Michael J Angove,; John D Wells,; Bruce B Johnson.Suitability of N,O-bis(trimethylsilyl)trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide as derivatization reagents for the determination of the estrogens estrone and 17α-ethinylestradiol by gas chromatography-mass spectrometry. Journal of Chromatography A. 2004 , 1026 (1-2),295-300.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H314

Flammable liquid and vapour. Causes severe skin burns and eye damage.

Precautionary Statements: P210-P233-P240-P241-P242-P243-P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3607620
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2931.90
TSCA
Yes

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