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44483 Methyl (S)-(+)-3-hydroxy-2-methylpropionate, 99%

CAS Number
80657-57-4
Synonyms
(S)-3-Hydroxyisobutyric acid methyl ester
(S)-3-Hydroxy-2-methylpropionic acid methyl ester

Stock No. Size Price ($) Quantity Availability
44483-04 2g 81.60
44483-09 10g 352.00
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Methyl (S)-(+)-3-hydroxy-2-methylpropionate, 99%

MDL
MFCD00064520

Chemical Properties

Formula
C5H10O3
Formula Weight
118.13
Form
Liquid
Boiling Point
74°/10mm
Flash Point
81°(178°F)
Density
1.07
Refractive Index
1.4250
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water. Soluble in methanol.

Applications

Methyl (S)-(+)-3-hydroxy-2-methylpropionate is used as a starting material for the synthesis of dictyostatin, discodermolide and spongidepsin.

Notes

Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.

Literature References

Lee, P.; Raj, S. M.; Zhou, S.; Ashok, S.; Edwardraja, S.; Park, S. 3-hydroxyisobutyrate dehydrogenase-I from Pseudomonas denitrificans ATCC 13867 degrades 3-hydroxypropionic acid. Biotechnol. Bioprocess Eng. 2015, 19 (1), 1-7.

Subrao, M.; Potukuchi, D. M.; Ramachandra, G. S.; Bhagavath, P.; Bhat, S. G.; Maddasani, S. Novel biphenyl-substituted 1, 2, 4-oxadiazole ferroelectric liquid crystals: synthesis and characterization. Beilstein J. Org. Chem. 2015, 11 (1), 233-241.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P235-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1720830
Harmonized Tariff Code
2918.19
TSCA
No

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