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44630 Trifluoroacetic acid, HPLC Grade, 99.5+%

CAS Number
76-05-1
Synonyms

Stock No. Size Price ($) Quantity Availability
44630-AE 100ml 113.00
44630-5Y *4x100ml 228.00
44630-AP 500ml 285.00
44630-AY *4x500ml 690.00
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Trifluoroacetic acid, HPLC Grade, 99.5+%

MDL
MFCD00004169
EINECS
200-929-3

Chemical Properties

Formula
CF3CO2H
Formula Weight
114.02
Form
Liquid
Melting point
-15°
Boiling Point
72-73°
Density
1.480
Refractive Index
1.2840
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Miscible with water, ether, acetone, ethanol, benzene, hexane and carbon tetrachloride.

Applications

The combination of properties like solubility in most of the solvents, volatility, catalytic property and strong acidity with non-oxidizing nature makes it a widely used reagent in an organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and ceramic compounds. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. It finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Notes

Trifluoroacetic acid is a strong non-oxidizing acid. It is a stable, hygroscopic, volatile and low-boiling organic acid.

Literature References

Kempe, H.; Yoshino, J.; Hayashi, N.; Higuch, H. A reversibly transformable chromatic system of the (octaethylporphyrin)-(dihexylbithiophene)-(Lewis base) triads. An evaluation of stereo-electronically controlled effects of dihexylbithiophene and Lewis base on its sensitivity and stability to trifluoroacetic acid. Tetrahedron 2015, 71 (8), 1322-1333.

López, S. E.; Salazar, J. Trifluoroacetic acid: Uses and recent applications in organic synthesis. J. Fluorine Chem. 2013, 156, 73-100.

Natu, A. D.; Burde, A. S.; Limaye, R. A.; Paradkar, M. V. Acceleration of the Dakin reaction by trifluoroacetic acid. J. Chem. Res. 2014, 38 (6), 381-382.

GHS Hazard and Precautionary Statements

Hazard Statements: H290-H314-H332-H335

May be corrosive to metals. Causes severe skin burns and eye damage. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P234-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P390-P501c

Keep only in original container. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,9681
Beilstein
742035
Hazard Class
8
Packing Group
I
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
AJ9625000

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