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Ethyl hydrogen malonate is used as a reactant for the preparation of tetramic acids through Dieckmann ring closure and organocatalytic decarboxylative Doebner-Knoevenagel reactions. It is involved in the acylation reactions and Knoevenagel condensation with aldehydes. It is also used in the preparation of gamma-lactones from olefins by intermolecular carbolactonization in presence of Mn(III) acetate as a catalyst.
Han, D.; Guo, Q. Y.; Zhang, W. B.; Liu, L. X.; Fu, Q. Preparation and properties of polystyrene nanocomposites containing dumbbell-shaped molecular nanoparticles based on polyhedral oligomeric silsesquioxane and  fullerene. RSC Adv. 2015, 5 (86), 70051-70058.
Pandit, R. P.; Lee, Y. R. Novel one-pot synthesis of diverse gamma, sigma-unsaturated beta-ketoesters by thermal cascade reactions of diazodicarbonyl compounds and enol ethers: transformation into substituted 3, 5-diketoesters. Org. Biomol. Chem. 2014, 12 (25), 4407-4411.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.